• !Diversification (aka How To Survive A Crash)
    I was emailing with my friend Harry this past week and we started talking about crypto and the inevitability of a massive crash. I am certain the big crash will happen. I don’t know when it will happen and I think it may be some time before it does…
    - 7 hours ago 24 Sep 17, 11:03am -
  • Video Of The Week: Matthew Zeiler at Code Commerce
    Matthew is the founder and CEO of our portfolio company Clarifai. Here is his talk (11mins) from last week’s Code Commerce conference in which he talks about how to use AI to grow your business.
    - 1 day ago 23 Sep 17, 12:40pm -
  • Feature Friday: Coinbase Vaults
    Vaults are the crypto equivalent of a savings account. If you have crypto assets that you don’t plan to spend/send frequently, you can put them in vault and get increased security. Coinbase has had a vault offering for Bitcoin for the past three ye…
    - 2 days ago 22 Sep 17, 9:21am -
  • Happy New Year
    Today is Rosh Hashanah, the Jewish New Year. I’d like to wish a happy new year to all my Jewish friends and colleagues and readers. I don’t personally identify as any particular religion. I was brought up Catholic, married into and raised our ch…
    - 3 days ago 21 Sep 17, 9:50am -
  • Mexico City
    Mexico City is an amazing place. The Gotham Gal and I were there around this time last year. The people, the culture, the energy are all great in Mexico City. It feels like a place on the move where good things are happening. So I was upset to hear a…
    - 4 days ago 20 Sep 17, 5:51pm -

Both Sides of The Table

  • Why the Former President of Nickelodeon Joined mitú as CEO.
    Why the Former President of Nickelodeon Joined mitú as CEO. (Hint: 60 million US Latinos driving US growth engine)I am beyond excited to announce the Herb Scannell has agreed to move from NYC to Los Angeles to take on the role of CEO at mitú, the…
    - 5 days ago 19 Sep 17, 7:45pm -
  • Want to Really Understand What all the Hype of Cryptocurrency is About?
    If you read the headlines you may well think cryptocurrencies are a either a radically new way of paying that is our savior from ossified, corrupt governments or on the other side that they are speculative Ponzi schemes. The reality of course is that…
    - 6 days ago 18 Sep 17, 3:44pm -
  • Finding My Tribe — The Upside of the Downcast Year
    It’s been a tough year globally. Many feel the division in our families and societies. It has been heart-breaking to see progress reversed and social & racial tensions exacerbated unnecessarily.Much of the focus on the public discourse has been how…
    - 38 days ago 17 Aug 17, 3:09pm -
  • 11 Quick Tips to Get More Value out of Your Board
    Many board meetings are bored meetings. Management teams whisk through slides trying to get through a presentation to share how great things are going and they are eager to get through the meeting so they can get back to their real jobs. This is a sh…
    - 39 days ago 16 Aug 17, 2:43pm -
  • What Do Boards Actually Do?
    There’s a lot of mystique about what happens at board meetings and a lot of imagined board-room drama. I read commentary or Twitter or blogs and realize that there are also strongly held convictions that there are these evil VCs who do terrible thi…
    - 41 days ago 15 Aug 17, 5:04am -

Tomasz Tunguz

  • How Much Should A SaaS Startup Invest in Sales & Marketing?
    How much should a SaaS startup invest in sales and marketing at different stages of the business? This is a very nuanced question, but benchmarks do provide some guidance for what is reasonable. Sales and marketing investment depends on many differ…
    - 8 days ago 17 Sep 17, 12:00am -
  • Ownership - A Defining Trait of a Leader
    One of the hardest things for me is to admit is when I’m wrong. It’s hard first to admit it to myself. But harder yet is to admit the error to others. It could be my wife or my colleagues. Most challenging of all is owning the error in a public…
    - 12 days ago 13 Sep 17, 12:00am -
  • Should You Consider Emotional Intelligence When Hiring Your Startup's Team?
    How important is hiring for emotional intelligence? EQ or EI was introduced in 1964 by Michael Beldoch and popularized by Daniel Goleman in 1995. I hear EQ uttered in nearly every job interview and evaluations, and assumed that high EQ correlated t…
    - 15 days ago 10 Sep 17, 12:00am -
  • The Challenges of the Platform Go To Market
    One of the most difficult go-to-market strategies for startups is platform. Platform go to markets mean selling software that can do many things, depending on the customer need. Selling a platform is challenging for five reasons.First, most custo…
    - 19 days ago 6 Sep 17, 12:00am -
  • The Theory and Data Underpinning Sales Commission Plans
    Every startup’s sales commission plan is different. But it’s key to understand the theory and the benchmark data that governs the creation of sales commission plans to create a good one for your business.Before we begin, let’s define a few…
    - 21 days ago 4 Sep 17, 12:00am -

Semil Shah

  • Who Startups Truly Compete With — Each Other
    When a founding team is raising institutional money — either an institutional seed or Series A/B round — those founding teams may have a slide in their pitch deck which shows the competition in their market or sector. This is often referred to as…
    - 2 days ago 23 Sep 17, 4:19am -
  • Quickly Unpacking Nestle’s Majority Investment In Blue Bottle Coffee
    Earlier this week, it was reported that Bay Area coffee roaster and coffee icon Blue Bottle received a massive investment from Nestle Corporation, giving it a majority stake in the company and, by some accounts, valuing it at or even above $700M (rep…
    - 7 days ago 18 Sep 17, 4:03am -
  • The Market Ignores Inputs
    About a decade ago, when I was finishing grad school and picking up various consulting engagements to keep afloat, I was reminded recently of one of those engagements. In the pursuit of as many leads as I could find, I accepted a statistical modeling…
    - 7 days ago 17 Sep 17, 6:07am -
  • Seeing Through The Hangover “Fog” From 2014-2015
    Earlier this week (on Monday the 11th), I wrote the following note to every CEO/founder I’ve invested in. I didn’t intend to write to write for it public consumption, but a bunch of them said it should be made public. So, I cleaned it up a bit an…
    - 12 days ago 13 Sep 17, 4:38am -
  • Three Founder Traits That Help Score Series As
    I’ve written here quite often — perhaps too much — about what early-stage founders need to think about when graduating from seed stage to institutional Series A stage. I won’t go into that here, but another aspect of this journey has been hig…
    - 24 days ago 31 Aug 17, 6:50am -

Brad Feld

  • !Book: Against Our Will: Men, Women and Rape
    “Men are afraid that women will laugh at them. Women are afraid that men will kill them.” – Margaret Atwood A few weeks ago, after reading the New York Times Sunday Review article The Book That Made Us Feminists, I asked Amy for several recomm…
    - 15 hours ago 24 Sep 17, 2:11am -
  • Last Chance to Sign Up For The Fall 2017 Venture Deals Course
    Kauffman Fellows and Techstars are running another cycle of the Venture Deals course with me and Jason Mendelson. Signups close tomorrow as the course runs from 9/24/17 – 11/13/17. The course is free to everyone. The seven-week course, which is ab…
    - 2 days ago 22 Sep 17, 1:59pm -
  • Seattle Screenings of For Here or To Go?
    Amy and I have been big supporters of a movie about immigration called For Here or To Go? With our friends at Boundless, we are sponsoring a week of screenings in Seattle. We are supplying a bunch of free tickets and – when they are used up – w…
    - 3 days ago 21 Sep 17, 4:01pm -
  • I’m Not Buying An iPhone 8
    For starters, let’s look at some Golden Retriever puppies instead. I watched most of the Apple announcement last week (I was on vacation and hanging out waiting for Amy, so I just plopped down on the floor and watched Special Events on the Apple TV…
    - 4 days ago 20 Sep 17, 2:41pm -
  • Engage in Boulder’s Upcoming Local Election
    Boulder has local elections every odd year. That means we are having a local election this year, with mail-in balloting starting on 10/16/17 and ending on 11/7/17. Because it’s on an odd-year cycle, turnout has historically been relatively low (und…
    - 5 days ago 19 Sep 17, 3:42pm -

Om Malik

  • I am taking a Facebook Vacation
    I am taking a bit of a vacation from Facebook — mostly because I find the social media is starting to become a bit distracting. It is not that I don’t like connecting to the people, but I am finding it hard to support a service that I am starting…
    - 1 day ago 23 Sep 17, 2:54pm -
  • Facebook, Elections & the Spin
    Mark Zuckerberg, on first day back from paternity leave, posted his response to the recent questions being raised about the company and its role in elections. Much of the sound and fury has been focused on the “Russian connection.” But focusing o…
    - 3 days ago 22 Sep 17, 4:30am -
  • Steve Jobs Theater… Some Photos
    “From the very beginning, I’ve protested the idea that an office headquarters, whether it’s mega or micro, is only about work. It’s about lifestyle.” Norman Foster, the architect who designed the new Apple’s Campus2. All photos made with…
    - 9 days ago 15 Sep 17, 11:48am -
  • Steve Jobs’ legacy & The iPhone X
    If you total up the energy spent debating the merits and demerits of the Apple iPhone X event and various devices announced today, odds are that you could actually power another keynote, one where the basic question is why: why does the iPhone X matt…
    - 11 days ago 13 Sep 17, 7:34pm -
  • Mile Rock Beach
    Mile Rock Beach, San Francisco, September 2017. Made with Fuji x100F. ISO 200, 3s at f/16 using an f2/23mm (35mm equivalent on full frame lens.)
    - 12 days ago 12 Sep 17, 1:08pm -


  • Venturing Boldly Into Neuroscience
    We've Moved! Update your Reader Now.This feed has moved to: https://lifescivc.com/feed/Update your reader now with this changed subscription address to get your latest updates from us.
    - 3 days ago 21 Sep 17, 11:48am -
  • Alternative Perspectives On The Biotech M&A Environment
    We've Moved! Update your Reader Now.This feed has moved to: https://lifescivc.com/feed/Update your reader now with this changed subscription address to get your latest updates from us.
    - 17 days ago 7 Sep 17, 12:08pm -
  • New Blood Needed: Pharma R&D Leadership Tenure
    We've Moved! Update your Reader Now.This feed has moved to: https://lifescivc.com/feed/Update your reader now with this changed subscription address to get your latest updates from us.
    - 19 days ago 5 Sep 17, 10:44am -
  • Crossing The Sea: Adventures In Transatlantic Biotech Operations
    We've Moved! Update your Reader Now.This feed has moved to: https://lifescivc.com/feed/Update your reader now with this changed subscription address to get your latest updates from us.
    - 31 days ago 24 Aug 17, 3:43pm -
  • Innately Innovative: IFM Therapeutics Acquired By BMS
    We've Moved! Update your Reader Now.This feed has moved to: https://lifescivc.com/feed/Update your reader now with this changed subscription address to get your latest updates from us.
    - 52 days ago 3 Aug 17, 8:02pm -


  • The Unknown Path to a Decentralized Future
    Today’s post is over at USV.com on “The Unknown Path to a Decentralized Future.” Here is the opening:Some companies with currently centralized services have been criticized for issuing tokens and raising money in ICOs. There are even allegation…
    - 2 days ago 22 Sep 17, 1:19pm -
  • Uncertainty Wednesday: Weather - Climate
    Last Uncertainty Wednesday I introduced how think about weather using the concepts we have developed in this series. We saw that our improved data collection and ability to process more complicated weather models has given us significantly improved p…
    - 4 days ago 20 Sep 17, 11:42am -
  • World After Capital: Progress Report
    My book World After Capital has been an ongoing project for a couple of years now. I am excited that as of this weekend I feel it includes all the ideas I want in there. Some of them, such as strategies for overcoming the dominance of nation states,…
    - 6 days ago 18 Sep 17, 1:30pm -
  • Uncertainty Wednesday: Weather (Intro)
    So far in Uncertainty Wednesday we have mostly built up concepts and ideas, with only one extended example.  Given the two massive hurricanes Harvey and Irma, the weather received a lot of attention, including the question to what extent the occurre…
    - 11 days ago 13 Sep 17, 8:46pm -
  • 9/11
    Going to work today will feel odd because the weather reminds me so much of 2001. Gorgeous blue skies. Not quite summer anymore, but also not yet fall. The weather is one of my strong memories from 2001.The other memory concerns later in the day. We…
    - 13 days ago 11 Sep 17, 11:33am -

Hunter Walk

  • Fake Cues: Why The Next Photo Innovation May Be Helping You Tell a Lie
    I want to share something which might be a bit unsettling – whenever I’m looking at you, I’m judging. Whether it’s in person or a static photo. I just can’t help it. It’s how I’m wired. By the way, it’s how you’re wired too. Perhaps…
    - 5 days ago 19 Sep 17, 2:41pm -
  • The Markets Ignore Inputs But Over Time, Not The Means
    When asked for advice about a career in tech my feedback varies based on the individual’s goals but always ends with “…you can recover from any failure except one where you ruined your reputation.” Basically, trying to make sure that the desi…
    - 6 days ago 18 Sep 17, 5:49pm -
  • Thinking About Bodega
    As investors, we hope to help founders see around corners in order to assess and predict outcomes. Startups, especially early stage startups, are in the weird position of simultaneously trying to reduce known risks while embracing new risks. Today, o…
    - 11 days ago 13 Sep 17, 10:28pm -
  • The Bot Registration Act of 2017 Could Improve Twitter For Us Humans
    This sounds like an X-Men storyline, but Twitter needs to ask all bot accounts to register as such & then badge. Bots can be very useful but users should know they’re following a bot & bots should follow certain ToS. Treat bots like a developer e…
    - 16 days ago 9 Sep 17, 2:05am -
  • The One Question Investors Should Ask Founders On Demo Day
    “What you’ve accomplished is really great and we’re excited to introduce ourselves and chat a bit more. Would you be willing to share your application to [incubator/accelerator] with us so that we can use it as a way to collaboratively discuss…
    - 26 days ago 29 Aug 17, 8:18pm -